Lifestyle changes that help promote healthy bones include increasing weight-bearing exercise, stopping smoking, limiting alcohol, and eating well-balanced meals that contain adequate calcium and vitamin D. You may also need to take calcium and vitamin D supplements. Consult your doctor for specific advice. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. No substantial differences in safety and efficacy relative to younger adults, but increased sensitivity cannot be ruled out. udol.info trazodone
But there was a 55% reduction in spine fracture risk in women who continued taking Fosamax for the extra five years, said Arthur Santora, executive director of clinical research for and endocrinology drugs at Merck, which makes the drug. Wood AJJ. Treatment of postmenopausal osteoporosis. N Engl J Med. Grossman JM, Gordon R, Ranganath VK et al. American College of Rheumatology 2010 recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis. Arthritis Care Res Hoboken. Do not stop taking any medications without consulting your healthcare provider.
Available as alendronate sodium; dosage expressed in terms of alendronate. Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. In patients requiring dental procedures, no data are available to suggest whether discontinuance of therapy prior to procedure reduces the risk of osteonecrosis of the jaw. 112 117 Base management of patients requiring dental treatment on an individual assessment of risks and benefits.
Ask your doctor or pharmacist to help select the best product for you. IU of vitamin D a day is safe for most people. American College of Rheumatology: "Osteonecrosis of the Jaw.
Read the Guide provided by your before you start taking this medication and each time you get a refill. Alendronate 10 mg once daily in postmenopausal women not receiving HRT. Constipation; diarrhea; dizziness; feeling bloated or full; flu-like symptoms at the start of treatment; gas; headache; mild back, muscle, or joint pain; mild stomach pain or upset; nausea; taste changes; vomiting. There has been some evidence that Actonel may work more quickly to prevent -- particularly the all-too-common hip and non-spine that can greatly reduce a person's quality of life. Caution is advised if you are or planning to become pregnant in the future. Alendronate may stay in your body for many years. Its effects on an unborn baby are unknown. Discuss the risks and benefits with your doctor before starting treatment with this medication. Make a list of all medications, vitamins and supplements that you're currently taking or have taken in the past. It's especially helpful if you record the type and dose of calcium and vitamin D supplements, because many different preparations are available. If you're not sure what information your doctor might need, take the bottles with you. Forteo is not used to prevent osteoporosis or to treat mild cases. What Are the Side Effects of Forteo? Adinoff AD, Hollister JR. Steroid-induced fractures and bone loss in patients with asthma. N Engl J Med. Long-term use of oral or injected corticosteroid medications, such as prednisone and cortisone, interferes with the bone-rebuilding process. Fosamax is available in generic form. Because long-term safety is not yet established, it is only FDA-approved for 24 months of use. Holick said at an online news conference. This drug is available at a higher level co-pay. However, he prescribed Fosamax. I purchase it, but before I took any, since I had never heard of Fosamax, I googled it and came to this web-site. I immediately came to the same conclusion others had. I would rather have a broken bone then suffer self-inflicted cronic illness. Next, I needed to get rid of the medication I had just purchased. I would not flush it because our city water is recycled. I did not want to just throw it away in case someone inadvertently got ahold of it. I decided to put it in a plastic baggy and add water then throw away. Imagine my surprise when the instant the water touched the pills they were instantly completely dissolved - instantly a white milky substance!
WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Fosamax is to be used only by the patient for whom it is prescribed. Do not share it with other people. Red 40, liquid sugar, methylparaben, propylparaben, sorbitol solution and wild cherry imitation flavor. Importance of swallowing tablets whole, without chewing or sucking. Do I need a prescription for alendronate? While the study was a long-term one, it perhaps gives better guidance on how to treat women who are 65 or older than women who are in their early 50s with borderline indications of osteoporosis and no evident fracture risk. Is it possible that you have something completely different going on in your back? Take this by with food. Ironically, my family doctor immediately told me to stop taking Fosamax. That was last Monday afternoon; I'd already taken my weekly dose that morning. At this point, I am praying that the pain and recurring spasms in my leg will fade or go away. Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. chloromycetin
Ask your doctor or pharmacist about using this product safely. National Institute of Arthritis and Musculoskeletal and Skin Diseases: "Once Is Enough: A Guide to Preventing Future Fractures. Pharmacologically inactive while incorporated into bone matrix. 1 2 3 4 11 112 Continuous administration required for activity. Your dosage is based on your medical condition, amount of sun exposure, diet, age, and response to treatment. Fosamax tablets alendronate sodium. FDA Med Bull. Bioavailability is negligible whether administered with or up to 2 hours after a meal.
Boniva a distant third, because it has not yet been shown to reduce hip fracture. Kweder said. "In the interim, it's important for patients and professionals to have all the safety information available. Calcium citrate. This is 21% elemental calcium. Some people taking alendronate may have serious jawbone problems. Your doctor should check your mouth before you start this medication. Tell your dentist that you are taking this medication before you have any dental work done. To help prevent jawbone problems, have regular dental exams and learn how to keep your teeth and gums healthy. If you have jaw pain, tell your doctor and dentist right away. Reclast, Skelid, and Zometa. 2008 Jan 7. Available from FDA website. American Academy of Family Physicians: "FDA Warns of Potential Side Effects of Bisphosphonate Use. Fosamax may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Fosamax with caution. purchase anastrozole remedio
FDA states that benefits of oral bisphosphonates continue to outweigh their potential risks in patients with osteoporosis; it is important to consider that esophageal cancer is rare, especially in women. Take it with a full glass 6-8 ounces or 180-240 milliliters of plain water. Swallow the tablet whole. not chew or suck on it. Then stay fully upright sitting, standing, or walking for at least 30 minutes and do not lie down until after your first food of the day. Alendronate incorporates into bone and selectively inhibits osteoclast-mediated bone resorption in a dose-dependent manner. Chewable tablets may contain sugar or aspartame. The body makes its own vitamin D if the skin is exposed to direct sunlight. But too much time in the direct sun raises the risk of -- and using cuts skin vitamin D production by 95%. Our Fosamax Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements, and diseases, and conditions. This may not be a complete list of all interactions that may occur. Ask your health care provider if Fosamax Plus D may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Disclosed are methods for inhibiting bone resorption in mammals while minimizing the occurrence of or potential for adverse gastrointestinal effects. Also disclosed are pharmaceutical compositions and kits for carrying out the therapeutic methods disclosed herein. This is especially true for patients with digestive problems. The findings probably can be generalized to weekly dosing of Fosamax, he said, but it's unclear how they relate to other bisphosphonates. Tell your doctor or dentist that you take Fosamax Plus D before you receive any medical or dental care, emergency care, or surgery. Alendronate 5 mg once daily in postmenopausal women receiving HRT, premenopausal women, and men. This drug may also be prescribed once weekly for osteoporosis. Check your prescription label carefully, and ask your doctor or pharmacist if you are not sure how to take this medication. Talk to your doctor about the risks and benefits of long-term use of this medication.
Caution is advised if you are pregnant or planning to become pregnant in the future. Alendronate may stay in your body for many years. Its effects on an unborn baby are unknown. Discuss the risks and benefits with your doctor before starting treatment with this medication. The two drugs are members of a class of drugs known as bisphosphonates, as is a newer drug, Roche's Boniva. Fosamax, none developed jaw osteonecrosis. Safety and effectiveness of Hycodan in pediatric patients under six have not been established. Potential decreased alendronate absorption when administered concomitantly with other oral medications. Who Should Take Forteo? During this time, bone mass is lost faster. No dosage adjustment required. Monitor serum calcium and monitor for symptoms of hypocalcemia during therapy. online apotheke domperidone 100mg
Office of Dietary Supplements: "Calcium. Most of the bisphosphonate patients who testified before the panel about their unusual thigh fractures said they had started taking the drugs in their 50s or 60s. You can get calcium supplements at most grocery stores and drugstores. They come in tablets, chewables, and capsules. Not all supplements contain the same amount of calcium or contain vitamin D. Read the label to see which one is best for you. Do not take this medication at or before rising for the day. It may not be absorbed and you may have side effects. Cleveland Clinic: "Temporomandibular Disorders. If you have any unusual effects, contact your doctor or promptly. Cholecalciferol vitamin D3 in this medication passes into breast milk. It is unknown if alendronate passes into breast milk. Consult your doctor before breast-feeding. For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products. That research failed to find a significant increase in esophageal cancer risk in users of the drugs. The guidelines, from the Endocrine Society, offer some contradictory advice.
Alendronate has been used concomitantly with hormone replacement therapy. Do not take these for at least 30 minutes preferably 1 to 2 hours after taking alendronate. Stayed upright the whole time. When I took the medicine, I felt like it lodged in my throat. I kept swallowing to get it moved down. I couldn't wait until I was able to safely eat something to get it pushed down my throat. I started feeling the effects of bloating and stomach gases by Wed. afternoon at work. By Thursday, my stomach was really upset. I could have spent the whole day in the bathroom. I was having diarreha, muscous in stool, a different odor and consistentency. I knew right away, the medicine was not agreeing with me. It felt like it was taking all of the fluids involved in my digestive track and distributing them throughout my body. These fluids are very good at digesting food and have their purpose, but need to remain where they are useful. It took me until the following Tuesday to get my body's system back to normal. I told my Doctor I was not taking this anymore. He now wants me to research Evista and see if I would consider taking it. I just read the reviews online. Side effects-Stroke, blood clots, leg cramps, severe hot flashes, weight gain. Sounds even worse. No thanks-I'm not being another test subject. I'm exercising and taking my calcium, vitamins, and all my calcium rich foods. Reid DM, Hughes RA, Laan RF et al. Efficacy and safety of daily risedronate in the treatment of corticosteroid-induced osteoporosis in men and women: a randomized trial. European Corticosteroid-induced osteoporosis treatment study. J Bone Miner Res. Low calcium intake. A lifelong lack of calcium plays a role in the development of osteoporosis. Low calcium intake contributes to diminished bone density, early bone loss and an increased risk of fractures. Scientists don't yet know the optimal daily dose of vitamin D for each person. A good starting point for adults is 600 to 800 international units IU a day, through food or supplements. For people without other sources of vitamin D and especially with limited sun exposure, a supplement may be needed. Plotkin LI, Weinstein RS, Parfitt AM et al. Prevention of osteocyte and osteoblast apoptosis by bisphosphonate and calcitonin. J Clin Invest. Karpf DB, Shapiro DR, Seeman E et al. Prevention of nonvertebral fractures by alendronate: a meta-analysis. JAMA. 1997; 277: 1159-64. Some bad habits can increase your risk of osteoporosis. AB1, AB2, AB3, etc. Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. National Institute of Dental and Craniofacial Research: "Bisphosphonate-Associated Osteonecrosis of the Jaw: Pathophysiology and Epidemiology. The condition, sometimes called jawbone death, occurs when bone in the jaw fails to heal after a minor trauma. It results in pain, swelling, infection, and exposed bone. Do not suck or chew tablets; potential oropharyngeal irritation. Estrogen without progestin estrogen therapy, or ET may be used to treat osteoporosis in women who have gone through and do not have a uterus. What types of side effects can I expect from treatment? nortriptyline
Your bone density can be measured by a machine that uses low levels of X-rays to determine the proportion of mineral in your bones. During this painless test, you lie on a padded table as a scanner passes over your body. Thyroid problems. Too much thyroid hormone can cause bone loss. This can occur if your thyroid is overactive or if you take too much thyroid hormone medication to treat an underactive thyroid. Now I'm sitting at my desk and I have horrible pain in between my shoulders radiating down my spine. It's obviously the med. I'm calling my doc and asking for something else. This is scary for me because when my grandmother passed away, she was so hunched over, her spine had to be broken in order for her to fit into the coffin. The thought of that is upsetting. I work in the nursing field and have witnessed first hand how a fracture alters ones quality of life. It affects both the physical and mental being. Food and Drug Administration. Fosamax alendronate sodium tablets and oral solution. Read the Medication Guide provided by your pharmacist before you start taking this medication and each time you get a refill. Follow the instructions very closely to make sure your body absorbs as much drug as possible and to reduce the risk of injury to your esophagus. If you have any questions, ask your doctor or pharmacist. FOSAMAX 35 mg and FOSAMAX 5 mg daily were similar. Sedghizadeh says in a news release. Abrahamsen B, et al. The risk of oesophageal and cancer incidence and mortality in alendronate users: a national cohort study. Presented at the 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society. Athens, Greece: May 10, 2011. Abstract No. 0C29. Known hypersensitivity to alendronate or any ingredient in the formulation. Medicine-Alendronate Sodium 70mg Tawat - I was diagnosed with Ostopenia. I took my one and only tablet on Wed. 1-7-09. Finkelstein JS. Osteoporosis. In: Bennett JC, Plum F, eds. Cecil textbook of medicine. How can you get enough calcium and vitamin D in your daily diet? Oxford University epidemiologist Jane Green, PhD, who led the latest research, says more study is needed to determine if bisphosphonate use really does increase esophageal cancer risk. One density measurement taken during treatment will not help the doctor plan or modify treatment. If you think you may have a serious medical problem, seek immediate medical attention.
Patients must have health insurance and their insurance must cover the qualifying medication for which they seek assistance. This combination is used to prevent or treat low levels in people who not get enough from their diets. Use Fosamax as directed by your doctor. Check the label on the medicine for exact dosing instructions. Just last month, an expert panel for the American Dental Association concluded that the risk of jaw osteonecrosis "apparently remains low" for people taking bisphosphonates. If you think you may have a serious medical problem, get medical help right away. Merck notes in a statement that the Sedghizadeh study contains methodological flaws and that the findings cannot be used to reach "valid scientific conclusions regarding the prevalence of osteonecrosis of the jaw" in patients taking Fosamax. Please refer to the for information on shortages of one or more of these preparations. American Academy of Otolaryngology -- Head and Neck Surgery: "TMJ. How is your balance? Estrogen, especially when started soon after menopause, can help maintain bone density. However, estrogen therapy can increase the risk of blood clots, endometrial cancer, breast cancer and possibly heart disease. Therefore, estrogen is typically used for bone health in younger women or in women whose menopausal symptoms also require treatment. Only recently have researchers realized that vitamin D is not harmful at the new, higher doses. lasix birmingham
What treatments are available, and which do you recommend? Heaney RP. Bone mass, bone loss, and osteoporosis prophylaxis. Ann Intern Med. Lindsay R, Cosman F, Lobo RA et al. Addition of alendronate to ongoing hormone replacement therapy in the treatment of osteoporosis: a randomized, controlled clinical trial. J Clin Endocrinol Metab. Too much can cause harmful high levels. Cheyne-Stokes respiration, cyanosis extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest and death may occur. The ingestion of very large amounts of Hycodan may, in addition, result in acute homatropine intoxication. What are the side effects of alendronate?
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Jeal W, Barradell LB, McTavish D. Alendronate: a review of its pharmacological properties and therapeutic efficacy in postmenopausal osteoporosis. Drugs. Drink at least 2 ounces 60 milliliters of plain water after taking liquid alendronate. Then stay fully upright sitting, standing, or walking for at least 30 minutes and not lie down until after your first food of the day. But if you are at high risk and cannot take other medicines, your doctor may recommend it under certain circumstances. Take this medication by mouth, after getting up for the day and before taking your first food, beverage, or other medication. Take it with a full glass 6-8 ounces or 180-240 milliliters of plain water. Swallow the tablet whole. Do not chew or suck on it. Then stay fully upright sitting, standing, or walking for at least 30 minutes and do not lie down until after your first food of the day. This product works only if taken on an empty stomach. Wait at least 30 minutes preferably 1 to 2 hours after taking the medication before you eat or drink anything other than plain water. duloxetine
Use Fosamax Plus D as directed by your doctor. Check the label on the medicine for exact dosing instructions. Alendronate 5 mg once daily in postmenopausal women receiving hormone replacement therapy HRT premenopausal women, and men. Dr. Henry G. Bone, lead author of the study appearing in the March 18 issue of the New England Journal of Medicine. "It also suggests that if somebody had to interrupt therapy, this isn't a crisis. The effect dissipates very slowly. It makes it no longer a supposition. We have some data. In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask questions during your appointment at any time that you don't understand something.
The report cited another 31 cases of the among bisphosphonate users in Europe and Japan. The loss of ones mobility is coupled with feeling frustrated and anxious about the loss of independence and can eventually lead to loss of self worth, will and hope. Decreased clearance of alendronate likely. But the panel backed off giving any specific time limits. GI malabsorption syndrome if necessary. 112 See Metabolic Effects under Cautions. cost of raloxifene allergy
Worsening of asthma has been reported in patients taking medicines like this one. Discuss any questions or concerns with your doctor. Gamble, Merck, Roche, and Sanofi are WebMD sponsors. Call for most recent medications as the list is subject to change and the medication for which you are seeking assistance must treat the disease directly. Note: All new enrollment is now done electronically or over the phone. Contact program for details. If a weekly dose is missed, administer missed dose the morning after it is remembered, followed by resumption of the regular weekly schedule. 1 112 However, do not take two 70-mg tablets on the same day.